Assessment of Salvia officinalis (L.) hydroalcoholic extract for possible use in cosmetic formulation as inhibitor of pathogens in the skin

  • Charlene Silvestin Celi Garcia
  • Mariana Roesch Ely
  • Ronaldo Adelfo Wasum
  • Bárbara Catarina Antoni Zoppa
  • Cláudia Wollheim
  • Gilda Ângela Neves
  • Valéria Weiss Angeli
  • Kellen Cristhinia Borges de Souza
Keywords: Hydroalcoholic extract of Salvia officinalis (L.). Phytochemical prospecting. Quality control. Bactericidal activity. Topical skin cleansing


Salvia officinalis (L.), or common sage, is an aromatic herb that has been used in medicine and cooking since ancient times and has been investigated for the treatment of various diseases, especially infections and skin inflammation. We conducted phytochemical prospecting and quality control with hydroalcoholic extracts of dried sage, to identify active compounds in the plant. The aim was to assess antibacterial and antifungal activity against Staphylococcus aureus, Streptococcus agalactiae, Candida albicans and Candida tropicalis. Antimicrobial susceptibility was investigated in vitro by agar-overlay and well-diffusion techniques, in which disc and well were used. Salvia officinalis (L.) was not effective against Streptococcus agalactiae, Candida albicans or Candida tropicalis, but best results were observed for antibacterial activity against Staphylococcus aureus. Considering the results of the inhibition tests presented here, we suggest that cosmetic formulations containing Salvia officinalis (L.) could contribute to inhibitor of pathogens in the skin microbiota.

Research Article